6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416412, compound

HRID 1015306Notes

Reaction equation

HRID 1015306 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH2:14]([N:16]([CH2:28][CH3:29])[C:17]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:18]=1[CH2:19][CH2:20][NH:21][CH:22]2[CH3:27])[CH3:15]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:21]3[CH2:20][CH2:19][C:18]4[C:23](=[CH:24][CH:25]=[CH:26][C:17]=4[N:16]([CH2:28][CH3:29])[CH2:14][CH3:15])[CH:22]3[CH3:27])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 66876062HCID 66876062, compound

Product 1

HCID 58416412HCID 58416412, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with Diethyl-(1-methyl-1,2,3,4-tetrahydro-isoquinolin-5-yl)-amine to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-84e1de9d000d406f86e0627cbeb38e41
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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