6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416403, compound

HRID 1015307Notes

Reaction equation

HRID 1015307 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH2:14]([N:16]([CH2:28][CH3:29])[C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:26]=1[CH:25]([CH3:27])[NH:24][CH2:23][CH2:22]2)[CH3:15]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:24]3[CH2:23][CH2:22][C:21]4[C:26](=[C:17]([N:16]([CH2:28][CH3:29])[CH2:14][CH3:15])[CH:18]=[CH:19][CH:20]=4)[CH:25]3[CH3:27])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 66875543HCID 66875543, compound

Product 1

HCID 58416403HCID 58416403, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with Diethyl-(1-methyl-1,2,3,4-tetrahydro-isoquinolin-8-yl)-amine to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-6f7858b26768471ab1e6a72a51d83337
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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