6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416495, compound

HRID 1015308Notes

Reaction equation

HRID 1015308 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH2:14]([N:16]([CH2:28][CH3:29])[C:17]1[CH:26]=[C:25]2[C:20]([CH2:21][CH2:22][NH:23][CH:24]2[CH3:27])=[CH:19][CH:18]=1)[CH3:15]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:23]3[CH2:22][CH2:21][C:20]4[C:25](=[CH:26][C:17]([N:16]([CH2:28][CH3:29])[CH2:14][CH3:15])=[CH:18][CH:19]=4)[CH:24]3[CH3:27])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 66875657HCID 66875657, compound

Product 1

HCID 58416495HCID 58416495, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with Diethyl-(1-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-amine to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-7ecdb8bfe9d64a328a4529b03a01b116
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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