6-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acid → HCID 58416323, compound

HRID 1015310Notes

Reaction equation

HRID 1015310 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[F:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][C:24]=1[F:25])[CH:21]([CH3:26])[NH:20][CH2:19][CH2:18]2>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:20]3[CH2:19][CH2:18][C:17]4[C:22](=[CH:23][C:24]([F:25])=[C:15]([F:14])[CH:16]=4)[CH:21]3[CH3:26])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 336956786-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acidHCID 66875780HCID 66875780, compound

Product 1

HCID 58416323HCID 58416323, compound

Procedure

In close analogy to the procedure described in Example 1, 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 6,7-difluoro-1-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-68cf24ee74fa4352a6f64ed861b54b88
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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