o-Xylyl bromide → 5-[1-(2-Methylbenzyl)piperidin-4-ylmethoxy]quinazoline-2,4-diamine

Beteiligte Stoffe

Reaktionsschritte

The benzylamine was obtained by reacting 5-(piperidin-4-ylmethoxy)quinazoline-2,4-diamine (75 mg; 0.27 mmol) and 2-methylbenzyl bromide (65 mg; 0.35 mmol) via Method BB to yield 91 mg. (89% yield). 1HNMR (400 MHz, DMSO-d6) δ 7.34 (t, J=8.0 Hz, 1H), 7.21 (m, 3H), 7.14 (m, 3H), 6.76 (d, J=8.0 Hz, 1H), 6.52 (d, J=8.4, 11H), 5.94 (br s, 2H), 3.98 (d, J=6.4 Hz, 2H), 3.41 (s, 3H), 2.83 (br, d, J=11.6 Hz, 2H), 2.32 (s, 3H), 2.00 (t, J=10.4 Hz, 2H), 1.9 (m, 1H), 1.73 (d, J=12.8 Hz, 2H), 1.31 (m, 2H). MS m/z (ESI) 378 (M+H)+.

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