Benzylamine → HCID 25007433, compound

Participants

Reaction Steps

The benzylamine was obtained by reacting 5-(piperidin-4-ylmethoxy)quinazoline-2,4-diamine (75 mg; 0.27 mmol) and 3-methylbenzyl bromide (60 mg; 0.32 mmol) via Method BB to yield 86 mg. (84% yield). 1HNMR (400 MHz, DMSO-d6) δ 7.34 (t, J=8.0 Hz, 1H), 7.2 (m, 3H), 7.07 (m, 3H), 6.76 (d, J=8.4 Hz, 1H), 6.52 (d, J=8.0 Hz, 1H), 5.94 (br s, 2H), 3.98 (d, J=6.0 Hz, 2H), 3.42 (s, 2H), 2.83 (br d, J=11.2 Hz, 2H), 2.29 (s, 3H), 1.8 (m, 5H), 1.36 (m, 2H). MS m/z (ESI) 378 (M+H)+.

Provenance & Evidence