Hydrochloric Acid → HCID 25007781, compound

Participants

Reaction Steps

The benzylamine was obtained by reacting 5-(piperidin-4-ylmethoxy)quinazoline-2,4-diamine (75 mg; 0.27 mmol) and 4-methylbenzyl bromide (60 mg; 0.32 mmol) via Method BB to a solid, which was stirred in the presence of 4M HCl in dioxane (4 eq). Solids were filtered and rinsed once with ether to give title compound. (101 mg; 90% yield). 1HNMR (400 MHz, DMSO-d6) δ 12.8 (s, 1H), 11.0 (s, 1H), 8.82 (s, 1H), 8.23 (s, 1H), 7.69 (m, 2H), 7.5 (d, J=8.0 Hz, 2H), 7.25 (d, J=8.0 Hz, 2H), 4.91 (br s, 2H), 4.17 (m, 4H), 3.36 (br d, J=11.6 Hz, 2H), 2.85 (m, 2H), 2.33 (s, 3H), 2.2 (m, 1H), 1.79 (m, 4H). MS m/z (ESI) 378 (M+H)+.

Provenance & Evidence