2-Fluorobenzoyl chloride → HCID 25007787, compound

Participants

Reaction Steps

The amidation of 5-(piperidin-4-ylmethoxy)quinazoline-2,4-diamine (50 mg; 0.18 mmol) was carried out using 2-fluorobenzoyl chloride (57 mg; 0.36 mmol) via Method AA to yield 43 mg. (60% yield). 1HNMR (400 MHz, DMSO-d6) δ 7.49 (m, 1H), 7.33 (m, 4H), 7.17 (br s, 2H), 6.77 (d, J=8.0 Hz, 1H), 6.54 (d, J=8.0 Hz, 1H), 5.94 (br s, 2H), 4.56 (br d, J=12.8 Hz, 1H), 4.03 (d, J=6.0 Hz, 2H), 3.42 (br d, J=12.8 Hz, 1H), 3.12 (m, 1H), 2.86 (t, J=11.2 Hz, 1H), 2.22 (br s, 1H), 1.89 (br d, J=13.6 Hz, 1H), 1.73 (br d, J=11.2 Hz, 1H), 1.26 (m, 2H). MS m/z (ESI) 396 (M+H)+.

Provenance & Evidence