2-Methylbenzoyl chloride → HCID 25002416, compound

Participants

Reaction Steps

The amidation of 5-(piperidin-4-ylmethoxy)quinazoline-2,4-diamine (50 mg; 0.18 mmol) was carried out using o-toluoyl chloride (57 mg; 0.37 mmol) via Method AA to yield 101 mg. (70% yield). 1HNMR (400 MHz, DMSO-d6) δ 7.35 (t, J=8.4 Hz, 1H), 7.25 (m, 6H), 6.76 (d, J=8.0 Hz, 1H), 6.54 (d, J=8.0 Hz, 1H), 5.94 (br s, 2H), 4.59 (br d, J=13.2 Hz, 1H), 4.03 (d, J=6.0 Hz, 2H), 3.3 (m, 1H), 3.04 (t, J=11.6 Hz, 1H), 2.88 (t, J=12.0 Hz, 1H), 2.23 (m, 4H), 1.89 (br d, J=13.2 Hz, 1H), 1.69 (m, 1H), 1.24 (m, 2H). MS m/z (ESI) 392 (M+H)+.

Provenance & Evidence