2,3-Difluorobenzoyl chloride → HCID 25002762, compound

Participants

Reaction Steps

The amidation of 5-(piperidin-4-ylmethoxy)quinazoline-2,4-diamine (50 mg; 0.18 mmol) was carried out using 2,3-difluorobenzoyl chloride (65 mg; 0.37 mmol) via Method AA to yield 114 mg. (74% yield). 1HNMR (400 MHz, DMSO-d6) δ 7.51 (q, J=8.8 Hz, 1H), 7.33 (m, 2H), 7.2 (m, 3H), 6.77 (d, J=8.4 Hz, 1H), 6.54 (d, J=8.0 Hz, 1H), 5.94 (br s, 2H), 4.54 (br d, J=12.8 Hz, 1H), 4.03 (d, J=6.0 Hz, 2H), 3.44 (d, J=14.0 Hz, 1H), 3.14 (t, J=12.4 Hz, 1H), 2.88 (m, 1H), 2.23 (s, 1H), 1.9 (d, J=12.4 Hz, 1H), 1.75 (d, J=10.8 Hz, 1H), 1.26 (m, 2H). MS m/z (ESI) 414 (M+H)+.

Provenance & Evidence