3,4-Difluorobenzene-1-sulfonyl chloride → HCID 25003477, compound

Participants

Reaction Steps

The sulfonamide was obtained by reacting 5-(piperidin-4-ylmethoxy)quinazoline-2,4-diamine (50 mg; 0.18 mmol) and 3,4-difluorobenzenesulfonyl chloride (79 mg; 0.37 mmol) via Method AA to yield 80 mg. (99% yield). 1HNMR (400 MHz, DMSO-d6) δ 7.88 (m, 1H), 7.73 (m, 1H), 7.65 (m, 1H), 7.33 (t, J=8.0 Hz, 1H), 7.11 (br s, 2H), 6.75 (dd, J=8.0, 0.4 Hz, 1H), 6.50 (d, J=7.6 Hz, 1H), 5.93 (br s, 2H), 3.97 (d, J=6.0 Hz, 2H), 3.69 (br d, J=11.6 Hz, 2H), 2.34 (m, 2H), 1.87 (m, 3H), 1.36 (m, 2H). MS m/z (ESI) 450 (M+H)+.

Provenance & Evidence