Hydrochloric Acid → HCID 67301835, compound

Participants

Reaction Steps

In a 50 ml beaker, Zn dust (3.6 g; 54 mmol) was added to 1N HCl and mixture was stirred with a glass rod. Aqueous was decanted off and solids were added to a mixture of trans-4-(3-chlorobenzoyl)cyclohexane-1-carboxylic acid (718 mg; 2.69 mmol) in 30 mL of formic acid. Mixture was heated to reflux for 2 hours. The reaction was cooled to room temperature and white solids were filtered off and rinsed with diethyl ether. Filtrate was concentrated and residue was taken up in a 40 mL mixture of diethyl ether and water (1:1). Organics were separated and aqueous was re-extracted with 2×20 mL of diethyl ether. Combined organics were washed with sat. NaHCO3, water, brine, and dried over MgSO4. Title compound was obtained as a crude oil. 550 mg (81% crude yield).

Provenance & Evidence