2,6-Difluorobenzonitrile → HCID 67301337, compound

Participants

Reaction Conditions

Reaction Steps

4-(2,6-Difluorophenoxy)cyclohexylmethanol (100 mg; 0.4 mmol) and 2,6-difluorobenzonitrile were combined in 3 mL of dimethylformamide under nitrogen flow and chilled to 0° C. Potassium t-butoxide (56 mg; 1.2 mmol) was added in portions. Mixture warmed to room temperature. After 4 hours reaction was quenched with 3 mL of water and mixture was extracted with 3×8 mL of ethyl acetate. Combined organics were washed with 5×8 mL of water, once with brine and dried over MgSO4. Crude oil was purified via flash chromatography using 0-20% ethyl acetate in hexanes to give 95 mgs of title compound. (66% yield).

Provenance & Evidence