Carbonic acid-guanidine (1:1) → HCID 25003846, compound

Participants

Reaction Steps

Cyclization of 2-[4-(2-chlorobenzyl)cyclohexylmethoxy]-6-fluorobenzonitrile (100 mg; 0.28 mmol) was carried out using Method F using guanidine carbonate (100 mg; 0.55 mmol) in 1.5 mL of dimethylacetamide. Title compound was obtained as a white solid. (88 mg; 79% yield). 1HNMR (400 MHz, DMSO-d6) δ 7.27 (m, 7H), 6.75 (d, J=8.0 Hz, 1H), 6.50 (d, J=7.6 Hz, 1H), 5.97 (br s, 2H), 3.92 (d, J=5.6 Hz, 2H), 2.52 (d, J=7.2 Hz, 2H), 1.83 (m, 3H), 1.68 (m, 3H), 1.06 (m, 4H). MS m/z (ESI) 398 (M+H)+.

Provenance & Evidence