反应详情

4-(4-Chlorophenyl)cyclohexane carboxylic acid (0.35 g, 1.5 mmol) was reacted via Method E over 72 hours. The solid was poured into a water (40 mL) solution and extracted with ethyl acetate (EtOAc) (4×10 mL). The combined organic layers were washed with brine (40 mL) and dried over anhydrous Na2SO4. The organic layer was concentrated in vacuo to obtain [4-(4-chlorophenyl)cyclohexyl]methanol (0.210 g, 64% yield).

1. extractionextracted with ethyl acetate (EtOAc) (4×10 mL)
2. washThe combined organic layers were washed with brine (40 mL)
3. dry with materialdried over anhydrous Na2SO4
4. concentrationThe organic layer was concentrated in vacuo