Benzyl Bromide → HCID 25004191, compound

Participants

Reaction Conditions

Reaction Steps

In a 20 mL vial with stir bar, triethylamine (40 mg; 0.4 mmol) was added to a mixture of 5-piperazin-1-yl-quinazoline-2,4-diamine (50 mg; 0.2 mmol) and benzyl bromide (45 mg; 0.27 mmol) in N,N-dimethylformamide and heated to 60° C. for 16 hours. Mixture was quenched with 1 mL of 1N NaOH and after 1.5 hours solids were collected by filtration and triturated with ethanol to obtain 43.1 mg of title compound. (64% yield).

Provenance & Evidence