Tris(hydroxymethyl)aminomethane → HCID 25004192, compound

Participants

Reaction Steps

5-piperazin-1-yl-quinazoline-2,4-diamine (50 mg; 0.2 mmol) was shaken for 96 hours at 47° C. in the presence of 3-(Morphonlino)propyl polystyrene sulfonamide (PS-NMM) (160 mg; 0.4 mmol) and o-methylbenzyl bromide (68.5 mg; 0.37 mmol) in 4 mL N,N-dimethylformamide. Tris-(2-aminoethyl)aminomethyl polystyrene (PS-Trisamine) (112 mg; 0.4 mmol) was then added to the mixture and continued to shake for an additional 2 hours. Resins were filtered off and rinsed with methanol. Filtrate was concentrated at reduced pressure, and residue was triturated 1N NaOH with ethanol. Solids were collected by filtration to yield 47.9 mg of title compound. (69% yield).

Provenance & Evidence