1-(Bromomethyl)-4-(trifluoromethoxy)benzene → HCID 25004867, compound

Participants

Reaction Steps

Title compound was prepared via Resin Method using 5-piperazin-1-yl-quinazoline-2,4-diamine (50 mg; 0.2 mmol) and 4-(trifluoromethoxy)benzyl bromide (94.4 mg; 0.37 mmol) to obtain 17.2 mg. (21% yield). 1H NMR (400 MHz, DMSO-d6) δ 12.6 (br s, 1H), 10.0 (br s, 1H), 9.01 (br s, 1H), 7.72 (m, 2H), 7.47 (m, 2H), 7.28 (m, 4H), 3.60 (s, 2H), 3.04 (d, J=10.4 Hz, 2H), 2.89 (m, 4H), 2.36 (m, 2H). ESIMS+419.8 m/z

Provenance & Evidence