1-(Bromomethyl)-3-(trifluoromethoxy)benzene → 5-[4-(3-Trifluoromethoxy-benzyl)-piperazin-1-yl]-quinazoline-2,4-diamine

Participants

Reaction Steps

Title compound was prepared via Resin Method using 5-piperazin-1-yl-quinazoline-2,4-diamine (50 mg; 0.2 mmol) and 3-(trifluoromethoxy)benzyl bromide (94.4 mg; 0.37 mmol) to obtain 58.9 mg. (70% yield). 1H NMR (400 MHz, DMSO-d6) δ 10.0 (br s, 1H), 8.97 (br s, 1H), 7.72 (m, 2H), 7.50 (m, 2H), 7.28 (m, 1H), 7.29 (m, 4H), 3.64 (s, 2H), 3.04 (d, J=10.4 Hz, 2H), 2.93 (m, 4H), 2.32 (m, 2H). ESIMS+419.8 m/z

Provenance & Evidence