1-Chloromethylnaphthalene → HCID 25004869, compound

Participants

Reaction Steps

Title compound was prepared via Resin Method using 5-piperazin-1-yl-quinazoline-2,4-diamine (50 mg; 0.2 mmol) and 1-(chloromethyl)naphthalene (65.4 mg; 0.37 mmol) to obtain 44.7 mg. (58% yield). 1H NMR (400 MHz, DMSO-d6) δ 10.0 (br s, 1H), 8.95 (br s, 1H), 8.30 (d, J=8.4 Hz, 1H), 7.92 (m, 2H), 7.69 (m, 1H), 7.55 (m, 1H), 7.49 (m, 5H), 7.23 (d, J=8.0 Hz, 1H), 7.19 (d, J=8.0 Hz, 1H), 3.99 (s, 2H), 3.0 (m, 6H), 2.38 (m, 2H). ESIMS+385.7 m/z

Provenance & Evidence