1,3-Benzodioxole, 5-(chloromethyl)- → HCID 25004870, compound

Participants

Reaction Steps

Title compound was prepared via Resin Method using 5-piperazin-1-yl-quinazoline-2,4-diamine (50 mg; 0.2 mmol) and 3,4-methylenedioxybenzyl chloride (63.1 mg; 0.37 mmol) to obtain 37.5 mg. (50% yield). 1H NMR (400 MHz, DMSO-d6) δ 9.34 (s, 1H), 7.92 (s, 1H), 7.51 (t, J=8.0 Hz, 1H), 7.04 (m, 2H), 6.85 (m, 3H), 6.65 (s, 2H), 6.0 (s, 2H), 3.47 (s, 2H), 2.99 (d, J=12.0 Hz, 2H), 2.85 (m, 4H), 2.24 (t, J=11.2 Hz, 2H).

Provenance & Evidence