4-Chlorobenzoyl chloride → HCID 25005212, compound

Participants

Reaction Steps

Title compound was prepared via Resin Method using 5-piperazin-1-yl-quinazoline-2,4-diamine (50 mg; 0.2 mmol) and 4-chlorobenzoyl chloride (71.8 mg; 0.41 mmol) to obtain 40.4 mg. (53% yield). 1H NMR (400 MHz, DMSO-d6) δ 8.77 (s, 1H), 7.53 (m, 4H), 7.39 (t, J=8.0 Hz, 1H), 7.15 (br s, 1H), 6.98 (d, J=8.5 Hz, 1H), 6.85 (d, J=8.0 Hz, 1H), 5.92 (br s, 2H), 4.56 (br s, 1H), 3.64 (m, 1H), 3.09 (m, 4H), 2.77 (m, 2H) ESIMS+384.1 m/z

Provenance & Evidence