2-Fluorobenzoyl chloride → HCID 25005215, compound

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Reaction Steps

Title compound was prepared via Resin Method using 5-piperazin-1-yl-quinazoline-2,4-diamine (50 mg; 0.2 mmol) and 2-fluorobenzoyl chloride (65 mg; 0.41 mmol) to obtain 40.2 mg. (55% yield). 1H NMR (500 MHz, DMSO-d6) δ 8.72 (s, 1H), 7.50 (m, 2H), 7.34 (m, 3H), 7.09 (br s, 1H), 6.98 (d, J=8.0 Hz, 1H), 6.83 (d, J=8.0 Hz, 1H), 5.93 (br s, 2H), 4.60 (br d, J=13.5 Hz, 1H), 3.46 (br s, 2H), 3.17 (m, 2H), 3.02 (m, 1H), 2.72 (m, 2H). ESIMS+368.0 m/z

Provenance & Evidence