2,3-Difluorobenzoyl chloride → HCID 25005569, compound

Participants

Reaction Steps

Title compound was prepared via Resin Method using 5-piperazin-1-yl-quinazoline-2,4-diamine (50 mg; 0.2 mmol) and 2,3-difluorobenzoyl chloride (72.4 mg; 0.41 mmol) to obtain 27.6 mg. (36% yield). 1H NMR (400 MHz, DMSO-d6) δ 8.71 (s, 1H), 7.54 (m, 1H), 7.34 (m, 3H), 7.11 (br s, 1H), 6.98 (d, J=8.0 Hz, 1H), 6.84 (d, J=8.0 Hz, 1H), 5.93 (br s, 2H), 4.60 (br d, 1H), 3.50 (br s, 2H), 3.18 (m, 2H), 3.02 (m, 1H), 2.73 (m, 2H).

Provenance & Evidence