2-Naphthoyl chloride → HCID 25005572, compound

Participants

Reaction Steps

Title compound was prepared via Resin Method using 5-piperazin-1-yl-quinazoline-2,4-diamine (50 mg; 0.2 mmol) and 2-Naphthoyl chloride (78.2 mg; 0.41 mmol) to obtain 61.6 mg. (77% yield). 1H NMR (500 MHz, DMSO-d6) δ 9.06 (s, 1H), 8.59 (s, 1H), 8.02 (m, 8H), 7.6 (m, 5H), 7.5 (t, J=8.0 Hz, 1H), 7.09 (d, J=8.5 Hz, 1H), 6.99 (d, J=7.5 Hz, 1H), 6.67 (br s, 2H), 4.64 (br s, 1H), 3.76 (br s, 1H), 3.42 (m, 4H), 2.85 (m, 2H).

Provenance & Evidence