2-Naphthalenesulfonyl chloride → HCID 25005931, compound

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Reaction Steps

Title compound was prepared via Resin Method using 5-piperazin-1-yl-quinazoline-2,4-diamine (50 mg; 0.2 mmol) and 2-naphthalene-sulfonyl chloride (79.8 mg; 0.41 mmol) to obtain 50.0 mg. (58% yield). 1H NMR (400 MHz, DMSO-d6) δ 8.52 (s, 1H), 8.31 (br s, 1H), 8.23 (m, 2H), 8.13 (m, 1H), 7.84 (m, 1H), 7.77 (m, 2H), 7.37 (m, 1H), 6.96 (d, J=8.0 Hz, 1H), 6.83 (m, 2H), 5.90 (br s, 2H), 3.82 (br d, J=11.2 Hz, 2H), 3.11 (br d, J=12.0 Hz, 2H), 2.87 (m, 2H), 2.64 (m, 2H). ESIMS+436.0 m/z

Provenance & Evidence