4-Chlorobenzenesulfonyl chloride → HCID 25005932, compound

Participants

Reaction Steps

Title compound was prepared via Resin Method using 5-piperazin-1-yl-quinazoline-2,4-diamine (50 mg; 0.2 mmol) and 4-chlorobenzene-sulfonyl chloride (86.5 mg; 0.41 mmol) to obtain 25.5 mg. (30% yield). 1H NMR (400 MHz, DMSO-d6) δ 8.34 (s, 1H), 7.78 (m, 4H), 7.38 (t, J=8.0 Hz, 1H), 6.96 (d, J=8.0 Hz, 1H), 6.92 (br s, 1H), 6.83 (d, J=7.6 Hz, 1H), 5.92 (br s, 2H), 3.73 (br d, J=11.6 Hz, 2H), 3.11 (br d, J=12.0 Hz, 2H), 2.84 (m, 2H), 2.62 (m, 2H). ESIMS+420.5 m/z

Provenance & Evidence