Triethylamine → HCID 25006304, compound

Participants

Reaction Steps

In an 8 mL vial triethylamine (40 mg; 0.4 mmol) was added to a mixture of 5-(2-piperazin-1-yl-ethoxy)-quinazoline-2,4-diamine trifluoroacetate (50 mg; 0.1 mmol) in 1.5 mL of tetrahydrofuran. 2-Fluorobenzene-sulfonyl chloride was added and reaction stirred at room temperature for 16 hours. Reaction was purified by reprecipitation with ethanol and (0.5:1) 1N NaOH. Solids were filtered to obtain 14 mg of title compound. (310% yield). 1H NMR (400 MHz, DMSO-d6) δ 7.77 (m, 3H), 7.48 (m, 2H), 7.32 (t, J=8.4 Hz, 1H), 7.18 (br s, 1H), 6.74 (d, J=8.4 Hz, 1H), 6.50 (d, J=7.6 Hz, 1H), 5.87 (br s, 2H), 4.16 (t, J=5.2 Hz, 2H), 3.17 (br s, 4H), 2.77 (t, J=5.2 Hz, 2H), 2.52 (m, 4H).

Provenance & Evidence