Water → HCID 86626212, compound

Participants

Reaction Conditions

Reaction Steps

4-Amino-4′-trifluoromethyl-biphenyl-3-carbonitrile (10 g) was dissolved in 250 ml of methanol and added 5.6 g of hydroxylamine hydrochloride and 8.1 g of triethylamine. The reaction mixture was stirred at 50° C. overnight, added 100 ml of water and 100 ml of ethyl acetate. The water phase was extracted with 100 ml of ethyl acetate. The organic phases was washed with 100 ml water and after that with 100 ml saturated sodium chloride. The organic phase was dried with magnesium sulfate and evaporated to an oil. Yield 10.8 g (96%).

Provenance & Evidence