Ammonium thiocyanate → HCID 25096337, compound

Participants

Reaction Steps

To a stirred solution of 4-fluorobenzoyl chloride (38 mg, 0.24 mmol) in acetone (2.0 mL) was added ammonium thiocyanate (51 mg, 0.66 mmol). The resulting mixture was stirred for 1 h at room temperature followed by the addition of the above-obtained tetrahydroquinoline compound (80 mg, 0.22 mmol). After stirred overnight at room temperature, the reaction mixture was quenched with excess saturated ammonium chloride (20 mL) followed by extraction with ethyl acetate (3×20 L). The organic layers were combined, washed with brine, and then concentrated under vacuum. The residue was purified by silica gel chromatography to give 4-fluoro-N-{5-[5-(naphthalen-1-yloxy)-pentyloxy]-3,4-dihydro-2H-quinoline-1-carbothioyl}-benzamide (83 mg, 0.15 mmol, 70%) as a white solid. MS (EI): m/z 543 (M+H).

Provenance & Evidence