Hydrochloric Acid → HCID 67300418, compound

Participants

Reaction Conditions

Reaction Steps

A 587 mg portion of ethyl 2-ethyl-1-(4-fluorobenzyl)-3-methyl-1H-indole-5-carboxylate was dissolved in 10.5 ml of ethanol, and 3.5 ml of a 1 M sodium hydroxide aqueous solution was added, followed by overnight stirring at 80° C. Under ice-cooling, 1 M hydrochloric acid and water were added thereto, followed by stirring at pH 1 for 1 hour. Then, the resulting solid was collected by filtration to obtain 498 mg of 2-ethyl-1-(4-fluorobenzyl)-3-methyl-1H-indole-5-carboxylic acid as a pale pink solid.

Provenance & Evidence