Triethylsilane → HCID 57608633, compound

Participants

Reaction Conditions

Reaction Steps

A 460 mg portion of ethyl 1-benzyl-2,3-dimethyl-1H-indole-5-carboxylate was dissolved in 15 ml of trifluoroacetic acid, and 1.19 ml of triethylsilane was added at room temperature, followed by stirring at 50° C. for 3 hours. After evaporation of the solvent, ethyl acetate was added, followed by washing with a 1 M sodium hydroxide aqueous solution and saturated brine and subsequent drying over anhydrous sodium sulfate. After evaporation of the solvent, the residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:30 to 1:20) to obtain 437 mg of ethyl 1-benzyl-2,3-dimethylindoline-5-carboxylate as a pale yellow liquid.

Provenance & Evidence