Sodium borohydride → HCID 67300527, compound

Participants

Reaction Steps

A 415 mg portion of 1-benzyl-N-(diaminomethylene)-3-formyl-1H-indole-5-carboxamide was suspended in 15 ml of methanol, 98 mg of sodium borohydride was added at 0° C., followed by stirring at room temperature for 1.5 hours. After evaporation of the solvent and subsequent addition of water, the thus precipitated solid was purified by silica gel column chromatography (Clomatorex (registered trademark), methanol:chloroform:water=50:1:0.1 to 30:1:0.1 to 20:1:0.1 to 10:1:0.1). The thus obtained product was crystallized from methanol/water to obtain 325 mg of 1-benzyl-N-(diaminomethylene)-3-hydroxymethyl-1H-indole-5-carboxamide as a pale pink solid.

Provenance & Evidence