Hydrochloric Acid → HCID 67017891, compound

Participants

Reaction Steps

To a stirred solution of the compound obtained in step I above (0.2 g, 0.62 mmol) in EtOAc (2.0 mL) cooled to ice bath temperature was added a solution of dry HCl in EtOAc (3N, 3 mL). The reaction mixture was stirred at the same temperature for 2 h and the volatiles were removed under reduced pressure to obtain the crude product, which was triturated with ether several times to obtain pure hydrochloride salt of 1-(1H-tetrazol-1-ylmethyl)tricyclo[3.3.1.03,7]nonan-3-amine (160 mg) in 100% yield. m/z (M+1) 220; 1H NMR (CD3OD) 300 MHz δ 8.72 (s, 1H), 4.70 (s, 2H), 2.52-2.43 (m, 1H), 2.42-2.37 (m, 1H), 2.0-1.80 (m, 5H), 1.70-1.50 (m, 5H).

Provenance & Evidence