Hydrochloric Acid → HCID 131729072, compound

Participants

Reaction Steps

To a stirred solution of the compound obtained from step I (0.25 g, 0.98 mmol) in EtOAc (1 mL) cooled to ice bath temperature was added a solution of dry HCl in EtOAc (3N, 3 mL). After stirring the reaction mixture for 2 h, the volatiles were removed under reduced pressure. The crude product was triturated with ether several times to obtain 1-fluorotricyclo[3.3.1.03,7]nonan-3-amine, hydrochloride salt (0.19 g) in 99% yield. m/z (M+1) 156; 1H NMR (DMSO-d6) 300 MHz δ 8.45 (s (br), 2H), 2.47-2.18 (m, 4H), 1.96-1.72 (m, 6-H), 1.63 (dd, J=2.6, 9.5 Hz, 1H), 1.50-1.42 (m, 1H).

Provenance & Evidence