3,3-Difluoroazetidine hydrochloride → HCID 24772540, compound

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Reaction Steps

The title compound was prepared from the product of Example 50A and commercially available 3,3-difluoroazetidine hydrochloride by the procedure described for Example 2B. 1H NMR (DMSO-d6, 300 MHz) δ 1.30 (d, J=6.4 Hz, 3H), 4.30-4.51 (m, 4H), 4.89-5.02 (m, 2H), 5.17-5.26 (m, 1H), 7.80 (d, J=8.5 Hz, 1H), 8.03 (dd, J=8.0, 8.0 Hz, 1H), 11.85 (br s, 1H). MS (ESI+) m/z 499 (M+H)+. Anal. calcd. for C19H13ClF6N2O3S: C, 45.75; H, 2.63; N, 5.62. Found: C, 46.17; H, 2.51; N, 5.33.

Provenance & Evidence