2-Fluoro-6-(trifluoromethyl)benzoyl chloride → 2-fluoro-N-[4-methyl-3-(tetrahydro-2H-pyran-4-ylcarbonyl)-4,6-dihydrothieno[2,3-c]furan-2-yl]-6-(trifluoromethyl)benzamide

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Reaction Steps

The title compound was prepared from the product of Example 52A and 2-fluoro-6-trifluoromethylbenzoyl chloride by the procedure described for Example 1B. 1H NMR (DMSO-d6, 300 MHz) δ 1.33 (d, J=6.1 Hz, 3H), 1.64-1.71 (m, 4H), 3.01-3.10 (m, 2H), 3.34-3.43 (m, 1H), 3.82-3.93 (m, 2H), 4.89-5.04 (m, 2H), 5.36-5.45 (m, 1H), 7.75-7.85 (m, 3H), 12.08 (br s, 1H). MS (ESI+) m/z 493 (M+H)+.

Provenance & Evidence