3,3,3-Trifluoropropylamine hydrochloride → HCID 24772611, compound

HRID 1015596Notes

Reaction equation

HRID 1015596 reaction equation
[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[C:3]=1[C:4]([NH:6][C:7]1[S:18][C:10]2[C:11]([CH3:17])([CH3:16])[O:12][C:13]([CH3:15])([CH3:14])[C:9]=2[C:8]=1[C:19](O)=[O:20])=[O:5].Cl.[F:31][C:32]([F:37])([F:36])[CH2:33][CH2:34][NH2:35]>>[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:28])([F:27])[F:29])[C:3]=1[C:4]([NH:6][C:7]1[S:18][C:10]2[C:11]([CH3:16])([CH3:17])[O:12][C:13]([CH3:15])([CH3:14])[C:9]=2[C:8]=1[C:19]([NH:35][CH2:34][CH2:33][C:32]([F:37])([F:36])[F:31])=[O:20])=[O:5]

Participants

3

Reactant 2

HCID 252105053,3,3-Trifluoropropylamine hydrochlorideHCID 67300640HCID 67300640, compound

Product 1

HCID 24772611HCID 24772611, compound

Procedure

The title compound was prepared from the product of Example 45A and commercially available 3,3,3-trifluoropropylamine hydrochloride by the procedure described for Example 2B. 1H NMR (DMSO-d6, 300 MHz), 1.43 (s, 6H), 1.48 (s, 6H), 2.39-3.50 (m, 2H), 3.35-3.42 (m, 2H), 7.68-7.81 (m, 3H), 8.31 (t, J=5.4 Hz, 1H), 11.53 (br s, 1H). MS (ESI+) m/z 527 (M+H)+. Anal. calcd. for C22H21F7N2O3S: C, 50.19; H, 4.02; N, 5.32. Found: C, 50.30; H, 4.13; N, 5.00.

Sources & evidence

ORD record
ord-47dcd2bea5c24e9783fba5cf6dd57555
Source dataset
uspto-grants-2011_07
Patent number
US07985768B2

Reaction notes

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