2-(Trifluoromethyl)benzoyl chloride → Propyl 4,4,6,6-tetramethyl-2-{[2-(trifluoromethyl)benzoyl]amino}-4,6-dihydrothieno[2,3-c]furan-3-carboxylate

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Reaction Steps

The title compound was prepared from the product of Example 62A and commercially available 2-trifluoromethylbenzoyl chloride using the procedure described for Example 1B. 1H NMR (DMSO-d6, 300 MHz) δ 0.90 (t, J=7.5 Hz, 3H), 1.50 (s, 6H), 1.54 (s, 6H), 1.63-1.75 (m, 2H), 4.22 (t, J=6.8 Hz, 2H), 7.79-7.95 (m, 4H), 11.47 (br s, 1H). MS (ESI+) m/z 456 (M+H)+. Anal. calcd. for C22H24F3NO4S: C, 58.01; H, 5.31; N, 3.08. Found: C, 57.97; H, 5.37; N, 3.04.

Provenance & Evidence