2-Fluoro-6-(trifluoromethyl)benzoyl chloride → Propyl 2-{[2-fluoro-6-(trifluoromethyl)benzoyl]amino}-4,4,6,6-tetramethyl-4,6-dihydrothieno[2,3-c]furan-3-carboxylate

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Reaction Steps

The title compound was prepared from the product of Example 62A and commercially available 2-fluoro-6-(trifluoromethyl)benzoyl chloride using the procedure described for Example 1B. 1H NMR (DMSO-d6, 300 MHz) δ 0.90 (t, J=7.5 Hz, 3H), 1.49 (s, 6H), 1.54 (s, 6H), 1.62-1.74 (m, 2H), 4.20 (t, J=6.7 Hz, 2H), 7.74-7.88 (m, 3H), 11.61 (br s, 1H). MS (ESI+) m/z 474 (M+H)+. Anal. calcd. for C22H23F4NO4S: C, 55.81; H, 4.90; N, 2.96. Found: C, 56.11; H, 5.04; N, 3.01.

Provenance & Evidence