(S)-(+)-1-Aminopropan-2-ol → HCID 24772742, compound

Participants

Reaction Steps

The title compound was prepared from the product of Example 45A and commercially available (S)-2-hydroxypropylamine using the procedure described for Example 2B. 1H NMR (DMSO-d6, 300 MHz) δ 1.01 (d, J=6.1 Hz, 3H), 1.48 (s, 6H), 1.46 (s, 6H), 3.07-3.20 (m, 2H), 3.65-3.73 (m, 1H), 4.68 (d, J=4.4 Hz, 1H), 7.68-7.81 (m, 4H), 11.60 (br s, 1H). MS (ESI+) m/z 489 (M+H)+. Anal. calcd. for C22H24F4N2O4S: C, 54.09; H, 4.95; N, 5.73. Found: C, 53.91; H, 4.89; N, 5.38.

Provenance & Evidence