4-Fluoro-2-(trifluoromethyl)benzoyl chloride → Ethyl 2-{[4-fluoro-2-(trifluoromethyl)benzoyl]amino}-4,4,6,6-tetramethyl-4,6-dihydrothieno[2,3-c]furan-3-carboxylate

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Reaction Steps

The title compound was prepared from the product of Example 18A and commercially available 4-fluoro-2-(trifluoromethyl)benzoyl chloride using the procedure described for Example 1B. 1H NMR (DMSO-d6, 300 MHz) δ 1.30 (t, J=7.1 Hz, 3H), 1.49 (s, 6H), 1.54 (s, 6H), 4.30 (q, J=7.1 Hz, 2H), 7.76 (ddd, J=9.1, 8.6, 2.4 Hz, 1H), 7.88 (dd, J=9.3, 2.5 Hz, 1H), 7.96 (dd, J=8.6, 5.3 Hz, 1H), 11.48 (br s, 1H). MS (ESI+) m/z 460 (M+H)+. Anal. calcd. for C21H21F4NO4S: C, 54.90; H, 4.61; N, 3.05. Found: C, 54.84; H, 4.60; N, 3.02.

Provenance & Evidence