HCID 16074975, compound → HCID 16074983, compound

Participants

Reaction Steps

4-{[(2-Carboxy-5-phenyl-thiophen-3-yl)-(2,4-dichloro-benzoyl)-amino]-methyl}-piperidine-1-carboxylic acid benzyl ester (124 mg, 0.2 mmol) was dissolved in MeOH (2 mL) and treated with 10% Pd/C (200 mg) under H2 balloon. The reaction was stirred at room temperature for 18 h and the mixture was filtered on celite. The solution was evaporated to a residue that was purified by reverse-phase HPLC to provide 3-[(2,4-Dichloro-benzoyl)-piperidin-4-ylmethyl-amino]-5-phenyl-thiophene-2-carboxylic acid (17.3 mg, 18% yield). 1H NMR (CD3OD, 300 MHz): 7.55 (d, 1 H), 7.50 (m, 2 H), 7.27-7.39 (m, 4 H), 7.25 (s, 1 H), 7.18 (dd, 1 H), 4.12 (m, 1 H), 3.75 (m, 1 H), 3.43 (m, 2H), 2.96 (q, 2 H), 2.65 (d, 2 H), 2.05 (m, 1 H), 1.62 (m, 2 H).

Provenance & Evidence