Methanol → Methyl alpha-bromo-2-chlorophenylacetate

α-Bromo-2-chlorophenyl acetic acid (350.0 gm) was dissolved in methanol (1.18 Liter) and concentrated sulphuric acid (53.20 gm) was added. The reaction mixture was refluxed for 4 hours. After completion of the reaction, the reaction mixture was distilled out to get a syrupy mass. To the residual mass, water (560 ml) was added and the product was extracted into chloroform (560 ml). The chloroform layer was separated and was treated with 10% aqueous sodium bicarbonate solution (1.12 Litre). The chloroform extract was finally washed with water and chloroform was distilled out to get a syrupy mass to get the titled compound.

1. temperatureThe reaction mixture was refluxed for 4 hours
2. customAfter completion of the reaction
3. distillationthe reaction mixture was distilled out
4. customto get a syrupy mass
5. extractionthe product was extracted into chloroform (560 ml)
6. customThe chloroform layer was separated
7. additionwas treated with 10% aqueous sodium bicarbonate solution (1.12 Litre)
8. extractionThe chloroform extract
9. washwas finally washed with water and chloroform
10. distillationwas distilled out
11. customto get a syrupy mass

ORD record

ord-9c9a34bab362438d974081516afad4e4

Source dataset

uspto-grants-2011_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07985859B2