6-Bromo-3,4-dimethoxybenzaldehyde → 2-Bromo-5-hydroxy-4-methoxybenzaldehyde

HRID 1015914Notes

Reaction equation

HRID 1015914 reaction equation
[Br:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12]C)=[CH:6][C:3]=1[CH:4]=[O:5]>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([OH:12])=[CH:6][C:3]=1[CH:4]=[O:5]

Participants

3

Reactant 1

HCID 793516-Bromo-3,4-dimethoxybenzaldehyde

Product 1

HCID 6160682-Bromo-5-hydroxy-4-methoxybenzaldehyde

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

Compound B1 is demethylated in concentrated sulfuric acid to give 2-bromo-5-hydroxy-4-methoxybenzaldehyde (B2).

Sources & evidence

ORD record
ord-31103049d5834efc8d2339fb547c6f03
Source dataset
uspto-grants-2011_07
Patent number
US07985879B2

Reaction notes

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