反应详情

温度

30 °C

The previously prepared 2-bromo-5-hydroxy-4-methoxy benzoyl chloride (B13-Cl) in dichloromethane solution was transferred into the slurry of N-methyl-N-(2-[4-hydroxyphenyl]ethyl) amine at about 5° C. and then stirred for about 0.5 hours under an atmosphere of nitrogen. The solution was concentrated under vacuum and then cooled to between 25 to 35° C. To this was then added a 15% w/v solution of NaOH in methanol (0.173 Kg sodium hydroxide in methanol 0.910 Kg) and was then heated to between 25 to 35° C. The solution was stirred for about 8 hours and then the pH was adjusted to between 2 to 5 with 32% hydrochloric acid (˜0.6 Kg). The solution was concentrated and the residue was cooled to about 30° C. Dichloromethane (6.628 Kg) and water (15 Kg) were added into the above mixture and then cooled to about 5° C. and was then stirred for about 2 hours. The solidified product was filtered and washed twice with dichloromethane (0.663 Kg each) to provide crude N-methyl-N-(2-[4-hydroxyphenyl]ethyl)-2-bromo-5-hydroxy-4-methoxy benzene carboxamide (C2).

1. concentrationThe solution was concentrated under vacuum
2. additionTo this was then added a 15% w/v solution of NaOH in methanol (0.173 Kg sodium hydroxide in methanol 0.910 Kg)
3. temperaturewas then heated to between 25 to 35° C
4. stirringThe solution was stirred for about 8 hours
5. concentrationThe solution was concentrated
6. temperaturethe residue was cooled to about 30° C
7. additionDichloromethane (6.628 Kg) and water (15 Kg) were added into the above mixture
8. temperaturecooled to about 5° C.
9. stirringwas then stirred for about 2 hours
10. filtrationThe solidified product was filtered
11. washwashed twice with dichloromethane (0.663 Kg each)