5-(8-Hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)pyridine-2-carbonitrile → 5-(1-Hydroxy-4-oxocyclohexyl)pyridine-2-carbonitrile

HRID 1016004Notes

Reaction equation

HRID 1016004 reaction equation
[OH:1][C:2]1([C:12]2[CH:13]=[CH:14][C:15]([C:18]#[N:19])=[N:16][CH:17]=2)[CH2:11][CH2:10][C:5]2(OCC[O:6]2)[CH2:4][CH2:3]1.OC1(C2C=CC(C#N)=CC=2)CCC(=O)CC1>>[OH:1][C:2]1([C:12]2[CH:13]=[CH:14][C:15]([C:18]#[N:19])=[N:16][CH:17]=2)[CH2:11][CH2:10][C:5](=[O:6])[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 667870965-(8-Hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)pyridine-2-carbonitrileHCID 667872294-(1-Hydroxy-4-oxocyclohexyl)benzonitrile

Product 1

HCID 667873885-(1-Hydroxy-4-oxocyclohexyl)pyridine-2-carbonitrile

Procedure

The title compound was synthesized from 5-(8-hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)pyridine-2-carbonitrile using the same typical deprotection procedure as for 4-(1-hydroxy-4-oxocyclohexyl)benzonitrile.

Sources & evidence

ORD record
ord-81cd34fde2df4e24a3f0cac5f03084f8
Source dataset
uspto-grants-2011_07
Patent number
US07985730B2

Reaction notes

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