HCID 59556133, compound → HCID 59556152, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the ketone obtained in Step B (65 mg, 0.21 mmol) in THF (2 mL) cooled in an ice bath was added a 1 M solution of phenyl magnesium bromide in THF (0.25 mL). After being stirred at −78° C. for 3 hours, the reaction was quenched with aqueous ammonium chloride. The resulting solution was extracted with EtOAc 3 times. The combined EtOAc layers were dried over MgSO4 and concentrated. Flash chromatography on silica gel eluting with 5%, 10% and 50% MeOH/CH2Cl2 provided 27 mg of the title compound as a mixture of two isomers (7:3). MS calculated (M+H)+ 387. found 387.1.

Provenance & Evidence