3-Chlorobenzoic Acid → 4-Chloro-N-(1-(4-(4-chlorophenyl)-5,6-dihydropyridin-1(2H)-yl)-1-oxobutan-2-yl)benzamide

Participants

Reaction Steps

Example 224 was prepared in a similar manner as described for the preparation of Example 221 with the exceptions that 2-aminobutyric acid methyl ester hydrochloride was substituted for DL-alanine ethyl ester hydrochloride in Step 1, 4-chlorobenzoic acid was substituted for 3-chlorobenzoic acid in Step 2, and 4-(4-chlorophenyl)-4-hydroxypiperidine was substituted for 4-(4-chlorophenyl)piperidine hydrochloride in Step 4. Example 224 was provided by elimination during Step 5. MS found: (M+H)+=417.

Provenance & Evidence