Dimethylformamide dimethyl acetal → HCID 57890007, compound

Participants

Reaction Conditions

Reaction Steps

3-Acetyl-N—((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)benzamide was added DMF-DMA (0.3 mL) and the reaction mixture heated at 105° C. for ˜5 h. The residual DMF-DMA was removed on a rotovap and the crude product was dried on house high vac for ˜3 h to afford N—((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-((E)-3-(dimethylamino)acryloyl)benzamide.

Provenance & Evidence